Recombinant人CTDSP1 protein (ab105591)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9GZU7
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MDSSAVITQI SKEEARGPLR GKGDQKSAAS QKPRSRGILH SLFCCVCRDD GEALPAHSGA PLLVEENGAI PKTPVQYLLP EAKAQDSDKI CVVIDLDETL VHSSFKPVNN ADFIIPVEID GVVHQVYVLK RPHVDEFLQR MGELFECVLF TASLAKYADP VADLLDKWGA FRARLFRESC VFHRGNYVKD LSRLGRDLRR VLILDNSPAS YVFHPDNAVP VASWFDNMSD TELHDLLPFF EQLSRVDDVY SVLRQPRPGS
    • 分子量31 kDa including tags
    • 氨基酸1 to 260
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab105591 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab105591 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8

常规信息

  • 别名
    • Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1
    • Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
    • CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1
    • CTDS1_HUMAN
    • CTDSP1
    • NIF3
    • NLI IF
    • NLI interacting factor 3
    • NLI-IF
    • NLI-interacting factor 3
    • NLIIF
    • Nuclear LIM interactor interacting factor 3
    • Nuclear LIM interactor-interacting factor 3
    • SCP1
    • Small C-terminal domain phosphatase 1
    • Small CTD phosphatase 1
    see all
  • 功能Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
  • 组织特异性Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
  • 序列相似性Contains 1 FCP1 homology domain.
  • 细胞定位Nucleus. Colocalizes with RNA polymerase II.
  • Information by UniProt

Recombinant Human CTDSP1 protein 图像

  • 15% SDS-PAGE analysis of ab105591 (3ug)

Recombinant Human CTDSP1 protein (ab105591)参考文献

ab105591 has not yet been referenced specifically in any publications.

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