Recombinant人CSK protein (ab60764)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab60764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • C SRC
    • C SRC kinase
    • C src Tyrosine Kinase
    • C-SRC kinase
    • c-src tyrosine kinase
    • CSK
    • Csk A
    • CSK_HUMAN
    • CYTOPLASMIC TYROSINE KINASE
    • EC 2.7.10.2
    • MGC112926
    • MGC117393
    • MGC154049
    • P60 Src
    • Protein tyrosine kinase CYL
    • Protein-tyrosine kinase CYL
    • Proto oncogene tyrosine protein kinase
    • Tyrosine protein kinase CSK
    • Tyrosine-protein kinase CSK
    • zgc:154049
    see all
  • 功能
    Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
  • 组织特异性
    Expressed in lung and macrophages.
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 翻译后修饰
    Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.
  • 细胞定位
    Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
  • Information by UniProt

Recombinant human CSK protein 图像

  • Sample Kinase Activity Plot.
  • ab60764 on SDS-PAGE, MW ~52kDa.

Recombinant human CSK protein (ab60764)参考文献

ab60764 has not yet been referenced specifically in any publications.

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