Recombinant人CRY2 protein (ab114947)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ49AN0
    • 种属Human
    • 序列VEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVT SQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQG
    • 分子量36 kDa including tags
    • 氨基酸141 to 231

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技术指标

Our Abpromise guarantee covers the use of ab114947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • cry2
    • CRY2_HUMAN
    • Cryptochrome 2
    • cryptochrome 2 (photolyase like)
    • Cryptochrome-2
    • FLJ10332
    • growth inhibiting protein 37
    • HCRY2
    • KIAA0658
    • PHLL2
    • Photolyase like
    see all
  • 功能Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK
    NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK
    NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
  • 组织特异性Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.
  • 序列相似性Belongs to the DNA photolyase class-1 family.
    Contains 1 DNA photolyase domain.
  • 翻译后修饰Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.
    Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complex, leading to its degradation.
  • 细胞定位Cytoplasm. Nucleus. Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
  • Information by UniProt

Recombinant Human CRY2 protein 图像

  • 12.5% SDS-PAGE showing ab114947 at approximately 35.64kDa.
    Stained with Coomassie Blue.

Recombinant Human CRY2 protein (ab114947)参考文献

ab114947 has not yet been referenced specifically in any publications.

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