Recombinant人Coxsackie Adenovirus Receptor protein (ab114429)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP78310
    • 种属Human
    • 序列MALLLCFVLLCGVVDFARSLSITTPEEMIEKAKGETAYLPCKFTLSPEDQ GPLDIEWLISPADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKS GDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLVVLVKPSGARCYVDG SEEIGSDFKIKCEPKEGSLPLQYEWQKLSDSQKMPTSWLAEMTSSVISVK NASSEYSGTYSCTVRNRVGSDQCLLRLNVVPPSNKAGLIAGAIIGTLLAL ALIGLIIFCCRKKRREEKYEKEVHHDIREDVPPPKSRTSTARSYIGGNHS SLGSMSPSNMEGYSKTQYNQVPSEDFERTPQSPTLPPAKVAAPNLSRMGA IPVMIPAQSKDGSIV
    • 分子量66 kDa including tags
    • 氨基酸1 to 365

技术指标

Our Abpromise guarantee covers the use of ab114429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 46 kD coxsackievirus and adenovirus receptor CAR protein
    • 46 kD coxsackievirus and adenovirus receptor protein
    • CAR
    • CAR4/6
    • Coxsackie virus and adenovirus receptor
    • Coxsackie virus B receptor
    • Coxsackievirus and adenovirus receptor
    • Coxsackievirus B adenovirus receptor
    • Coxsackievirus B-adenovirus receptor
    • CVB3 binding protein
    • CVB3-binding protein
    • Cxadr
    • CXAR_HUMAN
    • hCAR
    • HCVADR
    see all
  • 功能Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.
  • 组织特异性Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
  • 序列相似性Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • 结构域The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML.
    The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.
  • 翻译后修饰N-glycosylated.
    Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.
  • 细胞定位Secreted and Cell membrane. Cell junction > tight junction. Cell junction > adherens junction. Basolateral cell membrane. In epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
  • Information by UniProt

Recombinant Human Coxsackie Adenovirus Receptor protein 图像

  • ab114429 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Coxsackie Adenovirus Receptor protein (ab114429)参考文献

ab114429 has not yet been referenced specifically in any publications.

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We have as yet not assessed theCoxsackie Adenovirus Receptor protein (ab114429) for its biological activity. We can therefore not be sure of if the protein will be able to bind to...

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