Recombinant人Cornulin protein (ab93883)

概述

  • 产品名称Recombinant人Cornulin protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸1 to 495

技术指标

Our Abpromise guarantee covers the use of ab93883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • 53 kDa putative calcium binding protein
    • 53 kDa putative calcium-binding protein
    • 53 kDa squamous epithelial induced stress protein
    • 53 kDa squamous epithelial-induced stress protein
    • 58 kDa heat shock protein
    • C1orf10
    • Chromosome 1 open reading frame 10
    • Cornulin
    • CRNN
    • CRNN_HUMAN
    • DRC1
    • PDRC1
    • SEP53
    • Squamous epithelial heat shock protein 53
    • Tumor related protein
    • Tumor-related protein
    see all
  • 功能Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
  • 组织特异性Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).
  • 序列相似性Belongs to the S100-fused protein family.
    Contains 1 EF-hand domain.
  • 结构域The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA.
  • 细胞定位Cytoplasm. Does not colocalize with TGM1.
  • Information by UniProt

Recombinant Human Cornulin protein 图像

  • 15% SDS-PAGE showing ab93883 at approximately 55.7kDa (3µg).

Recombinant Human Cornulin protein (ab93883)参考文献

ab93883 has not yet been referenced specifically in any publications.

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