Recombinant人Corneodesmosin protein (ab114567)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ15517
    • 种属Human
    • 序列KIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPSAGAKPCGSSSA GKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLNSP*
    • 分子量35 kDa including tags
    • 氨基酸442 to 529

技术指标

Our Abpromise guarantee covers the use of ab114567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AI747712
    • CDSN
    • CDSN_HUMAN
    • Corneodesmosin
    • D6S586E
    • DADB-141O4.5
    • Differentiated keratinocyte S protein
    • HTSS
    • S
    • S protein
    see all
  • 功能Important for the epidermal barrier integrity.
  • 组织特异性Exclusively expressed in skin.
  • 疾病相关Defects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
    Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.
  • 细胞定位Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • Information by UniProt

Recombinant Human Corneodesmosin protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human Corneodesmosin protein (ab114567)参考文献

ab114567 has not yet been referenced specifically in any publications.

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