Recombinant人COPS8 protein (denatured) (ab113601)

概述

  • 产品名称
    Recombinant人COPS8 protein (denatured)
  • 蛋白长度
    Full length protein
  • 描述
    Recombinant人COPS8 protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMPVAVMAESAFSFKKLLDQCENQELEAPGG IATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQR IWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIA DDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFI PLSEPAPVPPIPNEQQLARLTDYVAFLEN
    • 分子量
      25 kDa including tags
    • 氨基酸
      1 to 209
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 90 % SDS-PAGE.

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 10% Glycerol, 2.4% Urea, 0.32% Tris HCl

常规信息

  • 别名
    • COP9 homolog
    • COP9 signalosome complex subunit 8
    • COP9 signalosome subunit 8
    • Cops8
    • CSN8
    • CSN8_HUMAN
    • hCOP9
    • JAB1 containing signalosome subunit 8
    • JAB1-containing signalosome subunit 8
    • SGN8
    • Signalosome subunit 8
    see all
  • 功能
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 序列相似性
    Belongs to the CSN8 family.
    Contains 1 PCI domain.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab113601 (3 µg) at approximately 25.3 kDa.

文献

ab113601 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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