Recombinant人Contactin 1 protein (ab109353)

概述

  • 产品名称
    Recombinant人Contactin 1 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    HEK 293 cells
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      120 kDa including tags
    • 氨基酸
      1 to 993

技术指标

Our Abpromise guarantee covers the use of ab109353 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 内毒素水平
    < 0.100 Eu/µg
  • 纯度
    > 90 % SDS-PAGE.
    0.2µm-filtered solution in PBS.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

常规信息

  • 别名
    • CNTN
    • CNTN 1
    • Cntn1
    • CNTN1_HUMAN
    • Contactin-1
    • Contactin1
    • F3
    • F3cam
    • Glycoprotein gp135
    • gp 135
    • GP135
    • MYPCN
    • Neural cell surface protein F3
    see all
  • 功能
    Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
  • 组织特异性
    Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
  • 疾病相关
    Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM) [MIM:612540]. CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia.
  • 序列相似性
    Belongs to the immunoglobulin superfamily. Contactin family.
    Contains 4 fibronectin type-III domains.
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • 细胞定位
    Cell membrane.
  • Information by UniProt

文献

ab109353 has not yet been referenced specifically in any publications.

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