Recombinant人Constitutive androstane receptor protein (ab81846)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸101 to 348

技术指标

Our Abpromise guarantee covers the use of ab81846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

常规信息

  • 别名
    • CAR
    • CAR BETA
    • CAR1
    • CARA
    • Constitutive activator of retinoid response
    • constitutive active receptor
    • Constitutive active response
    • constitutive androstane nuclear receptor variant 2
    • constitutive androstane nuclear receptor variant 3
    • constitutive androstane nuclear receptor variant 4
    • constitutive androstane nuclear receptor variant 5
    • Constitutive androstane receptor
    • MB67
    • MGC97144
    • NR1I3
    • NR1I3_HUMAN
    • Nuclear receptor subfamily 1 group I member 3
    • orphan nuclear hormone receptor
    • Orphan nuclear receptor MB67
    • Orphan nuclear receptor NR1I3
    see all
  • 功能Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
  • 组织特异性Predominantly expressed in liver.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.
  • 翻译后修饰Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
  • 细胞定位Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Recruited to the cytoplasm by DNAJC7.
  • Information by UniProt

Recombinant Human Constitutive androstane receptor protein (ab81846)参考文献

ab81846 has not yet been referenced specifically in any publications.

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