Recombinant人Collagen III protein (ab73160)



  • 性质Recombinant
  • 来源Pichia pastoris
  • 氨基酸序列
    • 种属Human


Our Abpromise guarantee covers the use of ab73160 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用


  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明

    Recombinant collagens are essentially identical to the native collagen protein thereby reducing the risk of inflammation, immune response, and disease as compared to animal-sourced collagen.

  • Concentration information loading...


  • 稳定性和存储

    Shipped at 4°C. Store at +4°C.

    Component: 10mM HCl
    Preservatives: none.


  • 别名
    • CO3A1_HUMAN
    • COL 3A1
    • COL3A1
    • Collagen alpha 1(III) chain
    • Collagen alpha-1(III) chain
    • Collagen III alpha 1 chain precursor
    • Collagen III alpha 1 polypeptide
    • Collagen type III alpha
    • Collagen type III alpha 1
    • Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant)
    • EDS4A
    • Ehlers Danlos syndrome type IV, autosomal dominant
    • Fetal collagen
    • Type III collagen
    see all
  • 功能Collagen type III occurs in most soft connective tissues along with type I collagen.
  • 疾病相关Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM:130020]; also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity.
    Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4) [MIM:130050]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas.
    Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM:100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells.
  • 序列相似性Belongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
    Contains 1 VWFC domain.
  • 翻译后修饰Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Recombinant Human Collagen III protein (ab73160)参考文献

ab73160 has not yet been referenced specifically in any publications.

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Thank you for contacting us. I expect the collagen is in a neutral or acidic buffer but I was not able to confirm this. What we know is that the protein is produced as follows: DNA sequences encoding the human proalpha1 (III) and both alpha and b...

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