Recombinant人CLIC1 protein (ab119166)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO00299
    • 种属Human
    • 序列GSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
    • 分子量29 kDa including tags
    • 氨基酸1 to 241
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab119166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab119166 is purified by standard chromatography
  • 形式Liquid
  • 补充说明Please prevent freeze thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 10% Glycerol

常规信息

  • 别名
    • Chloride channel ABP
    • Chloride intracellular channel 1
    • Chloride intracellular channel protein 1
    • CLIC 1
    • CLIC1
    • CLIC1_HUMAN
    • G6
    • hRNCC
    • NCC 27
    • NCC27
    • Nuclear chloride ion channel 27
    • Nuclear chloride ion channel protein
    • p64CLCP
    • Regulatory nuclear chloride ion channel protein
    • RNCC protein
    see all
  • 功能Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
  • 组织特异性Expression is prominent in heart, placenta, liver, kidney and pancreas.
  • 序列相似性Belongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • 结构域Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • 翻译后修饰Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
  • 细胞定位Nucleus. Nucleus membrane. Cytoplasm. Cell membrane. Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt

Recombinant Human CLIC1 protein (ab119166)参考文献

ab119166 has not yet been referenced specifically in any publications.

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