Recombinant人CLCN3 protein (ab114666)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP51790
    • 种属Human
    • 序列MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGD TAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCK
    • 分子量37 kDa including tags
    • 氨基酸1 to 99

技术指标

Our Abpromise guarantee covers the use of ab114666 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein. Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Chloride channel 3
    • Chloride channel protein 3
    • Chloride channel, voltage-sensitive 3
    • Chloride transporter ClC 3
    • Chloride transporter ClC-3
    • Chloride transporter ClC3
    • ClC 3
    • ClC-3
    • ClC3
    • CLCN 3
    • CLCN3
    • CLCN3_HUMAN
    • DKFZp564I0463
    • H(+)/Cl(-) exchange transporter 3
    see all
  • 功能Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
  • 组织特异性Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).
  • 序列相似性Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
    Contains 2 CBS domains.
  • 结构域Isoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Membrane. Early endosome membrane. Late endosome membrane. Cytoplasmic vesicle > secretory vesicle membrane. Isoform 1 is localized mainly in early and late endosomes and Membrane. Early endosome membrane. Late endosome membrane. Golgi apparatus membrane. Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi.
  • Information by UniProt

Recombinant Human CLCN3 protein 图像

  • SDS-PAGE analysis of ab114666 on a 12.5% gel stained with Coomassie Blue.

Recombinant Human CLCN3 protein (ab114666)参考文献

ab114666 has not yet been referenced specifically in any publications.

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