Recombinant人Claudin 7 protein (ab112275)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      QMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAALQAT R
    • 分子量
      31 kDa including tags
    • 氨基酸
      31 to 81
    • 标签
      GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112275 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • CEPTR L2
    • CEPTRL 2
    • CEPTRL2
    • Claudin 1
    • Claudin 9
    • Claudin-7
    • Claudin1
    • Claudin7
    • Claudin9
    • CLD7_HUMAN
    • CLDN 7
    • CLDN-7
    • CLDN7
    • Clostridium perfringens enterotoxin receptor like 2
    • CPETR L2
    • CPETRL 2
    • CPETRL2
    • Hs.84359
    see all
  • 功能
    Plays a major role in tight junction-specific obliteration of the intercellular space.
  • 组织特异性
    Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
  • 序列相似性
    Belongs to the claudin family.
  • 翻译后修饰
    Phosphorylated.
  • 细胞定位
    Cell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE showing ab112275 at approximately 31.24kDa stained with Coomassie Blue.

文献

ab112275 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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