Recombinant人Claudin 7 protein (ab112275)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO95471
    • 种属Human
    • 序列QMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAALQAT R
    • 分子量31 kDa including tags
    • 氨基酸31 to 81
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112275 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • CEPTR L2
    • CEPTRL 2
    • CEPTRL2
    • Claudin 1
    • Claudin 9
    • Claudin-7
    • Claudin1
    • Claudin7
    • Claudin9
    • CLD7_HUMAN
    • CLDN 7
    • CLDN-7
    • CLDN7
    • Clostridium perfringens enterotoxin receptor like 2
    • CPETR L2
    • CPETRL 2
    • CPETRL2
    • Hs.84359
    see all
  • 功能Plays a major role in tight junction-specific obliteration of the intercellular space.
  • 组织特异性Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
  • 序列相似性Belongs to the claudin family.
  • 翻译后修饰Phosphorylated.
  • 细胞定位Cell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
  • Information by UniProt

Recombinant Human Claudin 7 protein 图像

  • 12.5% SDS-PAGE showing ab112275 at approximately 31.24kDa stained with Coomassie Blue.

Recombinant Human Claudin 7 protein (ab112275)参考文献

ab112275 has not yet been referenced specifically in any publications.

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