Recombinant人CKAP1 protein (ab117056)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ99426
    • 种属Human
    • 序列SLTIAEFKCKLELLVGSPASCMELELYGVDDKFYSKLDQEDALLGSYPVD DGCRIHVIDHSGARLGEYEDVSRVEKYTISQEAYDQRQDTVRSFLKRSKL
    • 分子量37 kDa including tags
    • 氨基酸31 to 130

技术指标

Our Abpromise guarantee covers the use of ab117056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • CG22
    • CKAPI
    • Cytoskeleton associated protein 1
    • Cytoskeleton associated protein CKAPI
    • Cytoskeleton-associated protein 1
    • Cytoskeleton-associated protein CKAPI
    • Tbcb
    • TBCB_HUMAN
    • Tubulin folding cofactor B
    • Tubulin specific chaperone B
    • Tubulin-folding cofactor B
    • Tubulin-specific chaperone B
    see all
  • 功能Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
  • 组织特异性Found in most tissues.
  • 序列相似性Belongs to the TBCB family.
    Contains 1 CAP-Gly domain.
  • 翻译后修饰Phosphorylation by PAK1 is required for normal function. Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.
  • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton. Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.
  • Information by UniProt

Recombinant Human CKAP1 protein 图像

  • 12.5% SDS-PAGE showing ab117056 at approximately 36.63 kDa.
    Stained with Coomassie Blue.

Recombinant Human CKAP1 protein (ab117056)参考文献

ab117056 has not yet been referenced specifically in any publications.

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