重组人CITED1蛋白(ab152541)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • 种属
      Human
    • 序列
      SMQLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQ SPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC
    • 分子量
      37 kDa including tags
    • 氨基酸
      94 to 193

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技术指标

Our Abpromise guarantee covers the use of ab152541 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ABCC1
    • AI316840
    • AU019144
    • Cbp/p300-interacting transactivator 1
    • Cbp/p300-interacting transactivator with GLU/ASP-rich C-terminal domain, 1
    • Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
    • CITE1_HUMAN
    • CITED1
    • melanocyte specific gene 1
    • Melanocyte specific protein 1
    • Melanocyte-specific protein 1
    • MSG1
    see all
  • 功能
    Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
  • 组织特异性
    Expressed only in melanocytes and testis.
  • 序列相似性
    Belongs to the CITED family.
  • 翻译后修饰
    Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.
  • 细胞定位
    Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152541 stained with Coomassie Blue.

文献

ab152541 has not yet been referenced specifically in any publications.

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