Recombinant人CISH protein (ab117057)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ9NSE2
    • 种属Human
    • 序列MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGT PAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMP EGTFLVRDSTHPSYLFTLSVKTTRGPTNVCIEYADSSFRLDSNCLSRPRI LAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAP PPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMAGY LRQYPFQL
    • 分子量54 kDa including tags
    • 氨基酸1 to 258

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技术指标

Our Abpromise guarantee covers the use of ab117057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • BACTS2
    • CIS
    • cis 1
    • CIS-1
    • CIS1
    • Cish
    • CISH_HUMAN
    • Cytokine inducible inhibitor of signaling type 1B
    • Cytokine inducible SH2 containing protein
    • Cytokine-inducible SH2-containing protein
    • G18
    • Protein G18
    • SOCS
    • Suppressor of cytokine signaling
    see all
  • 功能SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • 组织特异性Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • 翻译后修饰Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa).
  • Information by UniProt

Recombinant Human CISH protein 图像

  • 12.5% SDS-PAGE showing ab117057 at approximately 54.49 kDa.
    Stained with Coomassie Blue.

Recombinant Human CISH protein (ab117057)参考文献

ab117057 has not yet been referenced specifically in any publications.

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