功能Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.
序列相似性Belongs to the CINP family.
翻译后修饰Phosphorylated by CDC7 but not by CDK2.
细胞定位Nucleus. Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.