概述

  • 产品名称
    重组人CIITA蛋白
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      NSDADPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGD EETREAYANIAELDQYVFQDSQLEGLSKDIFKHIGPDEVIGESMEMPAEV GQKSQKRPFP
    • 分子量
      38 kDa including tags
    • 氨基酸
      39 to 148

技术指标

Our Abpromise guarantee covers the use of ab152530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • C2TA
    • C2TA_HUMAN
    • CIITA
    • CIITA IV
    • Class II major histocompatibility complex transactivator
    • Class II transactivator
    • MHC class II transactivator
    • MHC class II transactivator type III
    • MHC2TA
    • NLR family acid domain containing
    • NLRA
    • Nucleotide binding oligomerization domain leucine rich repeat and acid domain containing
    see all
  • 功能
    Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).
  • 疾病相关
    Bare lymphocyte syndrome 2
  • 序列相似性
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 结构域
    The acetyltransferase domain is necessary for activation of both class I and class II transcription.
    The GTP-binding motif doesn't confer GTPase activity but promotes nuclear localization.
  • 翻译后修饰
    Autophosphorylated, affecting interaction with TAF7.
  • 细胞定位
    Nucleus. Nucleus, PML body. Recruited to PML body by PML.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152530 stained with Coomassie Blue.

文献

ab152530 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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