Recombinant人CHMP6 protein (ab124606)

概述

  • 产品名称Recombinant人CHMP6 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ96FZ7
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MGSHMGNLFG RKKQSRVTEQ DKAILQLKQQ RDKLRQYQKR IAQQLERERA LARQLLRDGR KERAKLLLKK KRYQEQLLDR TENQISSLEA MVQSIEFTQI EMKVMEGLQF GNECLNKMHQ VMSIEEVERI LDETQEAVEY QRQIDELLAG SFTQEDEDAI LEELSAITQE QIELPEVPSE PLPEKIPENV PVKARPRQAE LVAAS
    • 分子量26 kDa including tags
    • 氨基酸1 to 201
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab124606 is purified by using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • Charged multivesicular body protein 6
    • chmp6
    • CHMP6_HUMAN
    • Chromatin modifying protein 6
    • Chromatin-modifying protein 6
    • FLJ11749
    • hVps 20
    • hVps20
    • novel SNF7 protein
    • OTTMUSP00000004363
    • RGD1565325
    • RP24 225K18.4
    • Vacuolar protein sorting associated protein 20
    • Vacuolar protein sorting-associated protein 20
    • Vps 20
    • Vps20
    see all
  • 功能Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Belongs to the SNF7 family.
  • 结构域The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
  • 细胞定位Endomembrane system. Endosome membrane. Late endosome membrane. Localizes to endosomal membranes.
  • Information by UniProt

Recombinant Human CHMP6 protein 图像

  • 15% SDS-PAGE showing ab124606 (3 µg).

Recombinant Human CHMP6 protein (ab124606)参考文献

ab124606 has not yet been referenced specifically in any publications.

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