Recombinant人CHMP2A protein (ab87754)

概述

  • 产品名称Recombinant人CHMP2A protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab87754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    purified by using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • BC2
    • Charged multivesicular body protein 2a
    • CHM2A_HUMAN
    • CHMP2
    • CHMP2a
    • Chromatin modifying protein 2a
    • Chromatin-modifying protein 2a
    • hVps2 1
    • hVps2-1
    • putative breast adenocarcinoma marker
    • Putative breast adenocarcinoma marker BC-2
    • Putative breast adenocarcinoma marker BC2
    • Vacuolar protein sorting associated protein 2 1
    • Vacuolar protein sorting-associated protein 2-1
    • VPS2
    • Vps2 1
    • Vps2-1
    • VPS2A
    see all
  • 功能Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
  • 序列相似性Belongs to the SNF7 family.
  • 结构域The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
  • 细胞定位Late endosome membrane. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
  • Information by UniProt

Recombinant Human CHMP2A protein 图像

  • ab87754 at 3µg visualized by 15% SDS-PAGE. Observed band size is approximately 35 kDa.

Recombinant Human CHMP2A protein (ab87754)参考文献

ab87754 has not yet been referenced specifically in any publications.

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