Recombinant人Chd1 protein (ab117050)

概述

  • 产品名称Recombinant人Chd1 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO14646
    • 种属Human
    • 序列IKALKDSSSGTERTGGRLGKVKGPTFRISGVQVNAKLVISHEEELIPLHK SIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGS
    • 分子量36 kDa including tags
    • 氨基酸1177 to 1272

技术指标

Our Abpromise guarantee covers the use of ab117050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ATP dependent helicase CHD 1
    • ATP-dependent helicase CHD1
    • CHD 1
    • CHD-1
    • Chd1
    • CHD1_HUMAN
    • Chromodomain helicase DNA binding protein 1
    • Chromodomain-helicase-DNA-binding protein 1
    • DKFZp686E2337
    • OTTHUMP00000222625
    see all
  • 功能ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
  • 序列相似性Belongs to the SNF2/RAD54 helicase family.
    Contains 2 chromo domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • 结构域The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).
  • 细胞定位Nucleus. Cytoplasm. Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
  • Information by UniProt

Recombinant Human Chd1 protein 图像

  • 12.5% SDS-PAGE showing ab117050 at approximately 36.19 kDa.
    Stained with Coomassie Blue.

Recombinant Human Chd1 protein (ab117050)参考文献

ab117050 has not yet been referenced specifically in any publications.

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