概述

  • 产品名称
    Recombinant人CENPB protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab73636 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    ab73636 reacts with Scleroderma patient sera.
  • 应用

    Western blot

    ELISA

  • 纯度
    > 90 % SDS-PAGE.
    ab73636 is purified by proprietary chromatographic techniques.
  • 形式
    Liquid
  • 补充说明
    ab73636 reacts with Scleroderma patient sera.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 250mM Sodium chloride, 20mM HEPES, pH 7.6

常规信息

  • 别名
    • CENP B
    • CENP-B
    • CENPB
    • CENPB_HUMAN
    • centromere autoantigen B
    • Centromere protein B
    • Centromere protein B, 80kDa
    • Major centromere autoantigen B
    see all
  • 功能
    Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
  • 序列相似性
    Contains 1 HTH CENPB-type DNA-binding domain.
    Contains 1 HTH psq-type DNA-binding domain.
  • 细胞定位
    Nucleus. Chromosome > centromere.
  • Information by UniProt

文献

This product has been referenced in:
  • Mohibi S  et al. Alteration/Deficiency in Activation 3 (ADA3) Protein, a Cell Cycle Regulator, Associates with the Centromere through CENP-B and Regulates Chromosome Segregation. J Biol Chem 290:28299-310 (2015). Read more (PubMed: 26429915) »
  • Favoino E  et al. Autoantibodies recognizing the amino terminal 1-17 segment of CENP-A display unique specificities in systemic sclerosis. PLoS One 8:e61453 (2013). WB . Read more (PubMed: 23613856) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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