来源 Escherichia coli
序列 MGSSHHHHHH SSGLVPRGSH MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR
分子量 26 kDa including tags
氨基酸 1 to 212
标签 His tag N-Terminus 技术指标
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
纯度 > 90
% SDS-PAGE. ab101667 was purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 40% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
Cdk associated protein phosphatase
CDK2 associated dual specificity phosphatase
功能 May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
疾病相关 Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].
序列相似性 Belongs to the protein-tyrosine phosphatase family.
细胞定位 Cytoplasm > perinuclear region.
Information by UniProt
Recombinant Human CDKN3 protein 图像
Recombinant Human CDKN3 protein (ab101667)参考文献
has not yet been referenced specifically in any publications.
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