This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cell division kinase 3
Cell division protein kinase 3
Cyclin dependent kinase 3
G1/S specific cyclin E
G1/S specific cyclin E1
CDK3 is a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
CCNE1 (Cyclin E) is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Functional Studies - CDK3 + CCNE1 protein (Active) (ab85643)
The Specific activity of ab85643 was determined to be 20 nmol/min/mg.
SDS-PAGE - CDK3 + CCNE1 protein (Active) (ab85643)
SDS-PAGE showing ab85643 at approximately 60kDa (CDK3) and 73kDa (CCNE1).
has not yet been referenced specifically in any publications.