Recombinant人CDC42 protein (ab82626)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 标签
      GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab82626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Sodium chloride, 20mM HEPES, 1mM EDTA, pH 7.5

  • 复溶
    Reconstitute in 20mM HEPES, pH 7.0, Packaging size : 0.2 mg

常规信息

  • 别名
    • CDC42
    • CDC42_HUMAN
    • CDC42Hs
    • Cell division control protein 42 homolog
    • Cell division cycle 42
    • Cell division cycle 42 (GTP binding protein 25kDa)
    • dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
    • dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
    • G25K
    • G25K GTP-binding protein
    • Growth regulating protein
    • GTP binding protein 25kDa
    • Small GTP binding protein CDC42
    • TKS
    see all
  • 功能
    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia.
  • 序列相似性
    Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
  • 翻译后修饰
    AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
  • 细胞定位
    Cell membrane.
  • Information by UniProt

图片

  • ab82626 at 1µg on SDS-PAGE.

文献

ab82626 has not yet been referenced specifically in any publications.

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