Recombinant人CDC42 Binding Protein Kinase Beta (ab56638)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human
    • 氨基酸1 to 473

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技术指标

Our Abpromise guarantee covers the use of ab56638 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific activity: 120 nmol/min/mg.
  • 应用

    SDS-PAGE

  • 形式Liquid
  • 补充说明

    ab204880 (RPS6 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • CDC42 binding protein kinase beta
    • CDC42-binding protein kinase beta
    • CDC42BPB
    • DMPK like beta
    • DMPK-like beta
    • KIAA1124
    • MRCK beta
    • MRCKB_HUMAN
    • Myotonic dystrophy kinase related CDC42 binding kinase beta
    • Myotonic dystrophy kinase-related CDC42-binding kinase beta
    • Myotonic dystrophy protein kinase like beta
    • Myotonic dystrophy protein kinase-like beta
    • Serine/threonine protein kinase MRCK beta
    • Serine/threonine-protein kinase MRCK beta
    see all
  • 功能May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.
  • 组织特异性Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 CNH domain.
    Contains 1 CRIB domain.
    Contains 1 PH domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 protein kinase domain.
  • 细胞定位Cytoplasm. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent.
  • Information by UniProt

Recombinant human CDC42 Binding Protein Kinase Beta 图像

  • SDS Page analysis of ab56638
  • Kinase Assay: Specific Activity 120nmol/min/mg.

Recombinant human CDC42 Binding Protein Kinase Beta (ab56638)参考文献

ab56638 has not yet been referenced specifically in any publications.

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