Recombinant人CD86 protein (ab114228)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP42081
    • 种属Human
    • 序列MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSL SELVVFWQDQENLVLNEVYLGKEKF DSVHSKYMGRTSFDSDSWTLRLH NLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNIT EN VYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTEL YDVSISLSVSFPDVTSNMTIFCILETDKT RLLSSPFSIELEDPQPPPD HIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQ TKKREK IHIPERSDETQRVFKSSKTSSCDKSDTCF
    • 分子量62 kDa including tags
    • 氨基酸1 to 329

技术指标

Our Abpromise guarantee covers the use of ab114228 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Activation B7-2 antigen
    • Activation B7-2 antigen 3
    • B-lymphocyte activation antigen B7-2
    • B-lymphocyte activation antigen B7-2 2
    • B7
    • B7 2
    • B7-2
    • B7.2
    • B70
    • B72 antigen
    • BU63
    • CD28 antigen ligand 2
    • CD28 antigen ligand 2 2
    • Cd28l2
    • CD28LG2
    • CD86
    • CD86 antigen
    • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
    • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2
    • CD86 molecule
    • CD86_HUMAN
    • CLS1
    • CTLA-4 counter-receptor B7.2
    • CTLA-4 counter-receptor B7.2 2, 3
    • Early T-cell costimulatory molecule 1
    • ETC-1
    • FUN 1
    • FUN-1
    • LAB72
    • Ly-58
    • Ly58
    • MB7
    • MB7-2
    • Membrane glycoprotein
    • MGC34413
    • T-lymphocyte activation antigen CD86
    • TS/A-2
    see all
  • 功能Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
  • 组织特异性Expressed by activated B-lymphocytes and monocytes.
  • 序列相似性Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • 翻译后修饰Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human CD86 protein 图像

  • 12.5% SDS-PAGE showing ab114228 at approximately 62.26kDa stained with Coomassie Blue.

Recombinant Human CD86 protein (ab114228)参考文献

ab114228 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"