Recombinant人CD79b protein (ab114420)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP40259
    • 种属Human
    • 序列MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSP RFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQ NESLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQ LKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLD IDQTATYEDIVTLRTGEVKWSVGEHPGQE
    • 分子量51 kDa including tags
    • 氨基酸1 to 229

技术指标

Our Abpromise guarantee covers the use of ab114420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AGM6
    • B cell antigen receptor complex associated protein beta chain
    • B cell specific glycoprotein B29
    • B-cell antigen receptor complex-associated protein beta chain
    • B-cell-specific glycoprotein B29
    • B29
    • B29/Ig-beta/CD79b
    • CD 79b
    • CD79b
    • CD79b antigen
    • CD79b antigen (immunoglobulin associated beta)
    • CD79b molecule
    • CD79b molecule immunoglobulin associated beta
    • CD79b protein
    • CD79B_HUMAN
    • Ig beta
    • Ig-beta
    • IGB
    • Igbeta
    • Immunoglobulin associated B29
    • Immunoglobulin associated B29 protein
    • Immunoglobulin associated beta
    • Immunoglobulin associated protein
    • Immunoglobulin-associated B29 protein
    • MGC108607
    see all
  • 功能Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
  • 组织特异性B-cells.
  • 疾病相关Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
  • 序列相似性Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • 翻译后修饰Phosphorylated on tyrosine upon B-cell activation.
  • 细胞定位Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt

Recombinant Human CD79b protein 图像

  • ab114420 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human CD79b protein (ab114420)参考文献

ab114420 has not yet been referenced specifically in any publications.

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