Recombinant人CD79a protein (ab112267)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP11912
    • 种属Human
    • 序列LWMHKVPASLMVSLGEDAHFQCPHNSSNNANVTWWRVLHGNYTWPPEFLG PGEDPNGTLIIQNVNKSHGGIYVCRVQEGNESYQQSCGTYLRVRQPPPRP FLDMGEGT
    • 分子量38 kDa including tags
    • 氨基酸33 to 140
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    SDS-PAGE

    Peptide Array

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced

常规信息

  • 别名
    • B lymphocyte-specific MB1 protein
    • B-cell antigen receptor complex-associated protein alpha chain
    • CD 79a
    • CD79a
    • CD79A antigen
    • CD79a antigen (immunoglobulin-associated alpha)
    • CD79a molecule, immunoglobulin-associated alpha
    • CD79A_HUMAN
    • Ig alpha
    • Ig-alpha
    • IGA
    • IgM-alpha
    • Immunoglobulin-associated alpha
    • Ly54
    • MB-1 membrane glycoprotein
    • MB1
    • Membrane-bound immunoglobulin-associated protein
    • Surface IgM-associated protein
    see all
  • 功能Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells.
  • 组织特异性B-cells.
  • 疾病相关Defects in CD79A are the cause of agammaglobulinemia type 3 (AGM3) [MIM:613501]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note=Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.
  • 序列相似性Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 ITAM domain.
  • 翻译后修饰Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
  • 细胞定位Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
  • Information by UniProt

Recombinant Human CD79a protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human CD79a protein (ab112267)参考文献

ab112267 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"