Recombinant人CD59 protein (ab126011)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP13987
    • 种属Human
    • 序列YNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTR LRENELTYYCCKKDLCNFNEQLEN
    • 分子量9 kDa
    • 氨基酸29 to 102

技术指标

Our Abpromise guarantee covers the use of ab126011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶Reconstitute with water to desired concentration.

常规信息

  • 别名
    • 16.3A5
    • 1F5
    • 1F5 antigen
    • 20 kDa homologous restriction factor
    • CD 59
    • CD_antigen=CD59
    • CD59
    • CD59 antigen
    • CD59 antigen complement regulatory protein
    • CD59 antigen p18 20
    • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
    • CD59 glycoprotein
    • CD59 molecule
    • CD59 molecule complement regulatory protein
    • CD59_HUMAN
    • Cd59a
    • Complement regulatory protein
    • EJ16
    • EJ30
    • EL32
    • FLJ38134
    • FLJ92039
    • G344
    • HRF 20
    • HRF-20
    • HRF20
    • Human leukocyte antigen MIC11
    • Ly 6 like protein
    • Lymphocytic antigen CD59/MEM43
    • MAC inhibitory protein
    • MAC IP
    • MAC-inhibitory protein
    • MAC-IP
    • MACIF
    • MACIP
    • MEM43
    • MEM43 antigen
    • Membrane attack complex (MAC) inhibition factor
    • Membrane attack complex inhibition factor
    • Membrane inhibitor of reactive lysis
    • MGC2354
    • MIC11
    • MIN1
    • MIN2
    • MIN3
    • MIRL
    • MSK21
    • p18 20
    • Protectin
    • Surface antigen recognized by monoclonal antibody 16.3A5
    • T cell activating protein
    see all
  • 功能Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
    The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
  • 疾病相关Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:612300].
  • 序列相似性Contains 1 UPAR/Ly6 domain.
  • 翻译后修饰N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.
    Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.
  • 细胞定位Cell membrane. Secreted. Soluble form found in a number of tissues.
  • Information by UniProt

Recombinant Human CD59 protein (ab126011)参考文献

ab126011 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab126011.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"