The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
< 0.100 Eu/µg
% SDS-PAGE. Purity is greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Monocyte differentiation antigen CD14
Monocyte differentiation antigen CD14 urinary form
Monocyte differentiation antigen CD14, membrane-bound form
Myeloid cell specific leucine rich glycoprotein
Myeloid cell-specific leucine-rich glycoprotein
Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Contains 11 LRR (leucine-rich) repeats.
N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.