Recombinant人CCM2 protein (ab113197)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9BSQ5
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMEEEGKKGKKPGIVSPFKRVFLKGEKSRDK KAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYL NPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDI ILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLD RAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGAS PHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGAS IHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGI ITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISS DIEALGCSMDQDSA
    • 分子量51 kDa including tags
    • 氨基酸1 to 444
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    Purity is >95%, by SDS-PAGE and silver stain.
  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • 复溶ab113197 is soluble in water and most aqueous buffers and should be reconstituted in water or medium containing at least 0.1% Human or BSA to a concentration not lower than 50 µg/ml.

常规信息

  • 别名
    • C7orf22
    • Ccm2
    • CCM2 gene
    • CCM2_HUMAN
    • Cerebral cavernous malformation 2
    • Cerebral cavernous malformations 2 protein
    • Chromosome 7 open reading frame 22
    • Malcavernin
    • MGC4067
    • MGC4607
    • MGC74868
    • OSM
    • Osmosensing scaffold for MEKK3
    • OTTHUMP00000159554
    • OTTHUMP00000214270
    • OTTHUMP00000214271
    • OTTHUMP00000214273
    • PP10187
    see all
  • 功能May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
  • 疾病相关Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2) [MIM:603284]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • 序列相似性Contains 1 PID domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human CCM2 protein 图像

  • SDS-PAGE of human recombinant CCM2 (ab113197). The sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with silver stain.

Recombinant Human CCM2 protein (ab113197)参考文献

ab113197 has not yet been referenced specifically in any publications.

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