Recombinant人CCK4 protein (ab114772)

概述

  • 产品名称Recombinant人CCK4 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ13308
    • 种属Human
    • 序列KQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSL SFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPA SEAEIQPQTQ
    • 分子量38 kDa including tags
    • 氨基酸36 to 145
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab114772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 8430404F20Rik
    • CCK 4
    • CCK-4
    • Colon carcinoma kinase 4
    • Human colon carcinoma kinase 4 (CCK4) mRNA complete cds
    • Inactive tyrosine-protein kinase 7
    • mPTK7/CCK4
    • OTTHUMP00000217016
    • Protein tyrosine kinase PTK 7
    • Protein-tyrosine kinase 7
    • Pseudo tyrosine kinase receptor 7
    • PTK 7
    • PTK7
    • PTK7 protein tyrosine kinase
    • PTK7 protein tyrosine kinase 7
    • PTK7_HUMAN
    • Serum response factor
    • Srf
    • Tyrosine-protein kinase-like 7
    see all
  • 功能Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
  • 组织特异性Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 结构域The protein kinase domain is predicted to be catalytically inactive.
  • 翻译后修饰MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
  • 细胞定位Membrane. Cell junction. Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
  • Information by UniProt

Recombinant Human CCK4 protein 图像

  • ab114772 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human CCK4 protein (ab114772)参考文献

ab114772 has not yet been referenced specifically in any publications.

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