Recombinant人CBFb protein (ab98252)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMPRVVPDQRSKFENEEFFRKLSRECEIKYT GFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQT PSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEE RAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTT RP
    • 分子量
      24 kDa including tags
    • 氨基酸
      1 to 182
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab98252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    >= 85 % SDS-PAGE.
    ab98252 was purified using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM MES, 0.1mM PMSF, pH 6.0

常规信息

  • 别名
    • CBF b
    • CBF beta
    • CBF-beta
    • CBFB
    • CBFbeta
    • Core binding factor beta subunit
    • core binding factor subunit beta
    • Core-binding factor subunit beta
    • PEA 2
    • PEA2
    • PEA2 beta
    • PEA2-beta
    • PEA2beta
    • PEBB_HUMAN
    • PEBP 2B
    • PEBP2 beta
    • PEBP2-beta
    • PEBP2B
    • PEBP2beta
    • Polyomavirus enhancer binding protein 2 beta subunit
    • Polyomavirus enhancer-binding protein 2 beta subunit
    • SL3 3 enhancer factor 1 beta subunit
    • SL3 3 enhancer factor 1 subunit beta
    • SL3-3 enhancer factor 1 subunit beta
    • SL3/AKV core binding factor beta subunit
    • SL3/AKV core-binding factor beta subunit
    see all
  • 功能
    CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
  • 疾病相关
    Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.
  • 序列相似性
    Belongs to the CBF-beta family.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of 3µg ab98252

文献

ab98252 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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