Recombinant人Cardiac Troponin C protein (ab70106)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 分子量18 kDa

技术指标

Our Abpromise guarantee covers the use of ab70106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab70106 was purified by proprietary chromatographic techniques. Purity is greater than 95.0% as determined by analysis by RP-HPLC, Anion-exchange FPLC and by reducing and non-reducing SDS-PAGE Silver Stained gel.
  • 形式Liquid
  • 补充说明For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C.

    Preservative: 0.05% Sodium Azide
    Constituents: 150mM Sodium chloride, 10mM Sodium phosphate, pH 7.0

常规信息

  • 别名
    • tnnc1a
    • Cardiac troponin C
    • slow skeletal and cardiac muscles
    • TN-C
    • TNC
    • Tnnc1
    • TNNC1_HUMAN
    • TNNI3
    • Troponin C
    • Troponin C slow
    • Troponin C1 slow
    see all
  • 功能Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
  • 疾病相关Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • 序列相似性Belongs to the troponin C family.
    Contains 4 EF-hand domains.
  • Information by UniProt

Recombinant Human Cardiac Troponin C protein (ab70106)参考文献

ab70106 has not yet been referenced specifically in any publications.

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