Recombinant人CARD4 protein (ab126000)

概述

  • 产品名称Recombinant人CARD4 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9Y239
    • 种属Human
    • 分子量25 kDa
    • 氨基酸710 to 936

技术指标

Our Abpromise guarantee covers the use of ab126000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶Reconstitute with water to desired concentration.

常规信息

  • 别名
    • CARD 4
    • CARD4
    • Caspase recruitment domain 4
    • Caspase recruitment domain containing protein 4
    • Caspase recruitment domain family member 4
    • Caspase recruitment domain protein 4
    • Caspase recruitment domain-containing protein 4
    • CLR 7.1
    • CLR7.1
    • NLR family CARD domain containing 1
    • NLRC 1
    • NLRC1
    • NOD 1
    • Nod1
    • NOD1 protein
    • NOD1_HUMAN
    • Nucleotide binding oligomerization domain containing 1
    • Nucleotide binding oligomerization domain leucine rich repeat and CARD domain containing 1
    • Nucleotide-binding oligomerization domain-containing protein 1
    • Protein Nod1
    see all
  • 功能Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
  • 组织特异性Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
  • 序列相似性Contains 1 CARD domain.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 翻译后修饰Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.
  • 细胞定位Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
  • Information by UniProt

Recombinant Human CARD4 protein (ab126000)参考文献

ab126000 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab126000.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"