Recombinant人CARD14 protein (ab38230)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab38230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5

常规信息

  • 别名
    • Bcl10 interacting MAGUK protein 2
    • Bimp 2
    • Bimp2
    • CAR14_HUMAN
    • CARD 14
    • CARD containing MAGUK 2 protein
    • CARD containing MAGUK protein 2
    • Card maguk protein 2
    • CARD-containing MAGUK protein 2
    • CARD14
    • Carma 2
    • Carma2
    • Caspase recruitment domain containing protein 14
    • Caspase recruitment domain family member 14
    • Caspase recruitment domain protein 14
    • Caspase recruitment domain-containing protein 14
    • PRP
    • PSORS2
    • PSS1
    see all
  • 功能Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
  • 组织特异性Expressed in placenta. Also detected in HeLaS3 cell line, but not in the other cancer cell lines tested. Expressed in epidermal keratinocytes.
  • 疾病相关Defects in CARD14 are the cause of susceptibility to psoriasis type 2 (PSORS2) [MIM:602723]. A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
    Defects in CARD14 are the cause of pityriasis rubra pilaris (PRP) [MIM:173200]. A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.
  • 序列相似性Contains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human CARD14 protein 图像

  • Analysis of CARD14 Recombinant Protein, the purified protein shows a band at 50 kDa. Commassie blue stained gel.

Recombinant Human CARD14 protein (ab38230)参考文献

ab38230 has not yet been referenced specifically in any publications.

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