Recombinant人CaMKK protein (ab55692)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab55692 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific Activity: 10 nmol/min/mg
  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • 补充说明

    ab43614 (Human Myelin Basic Protein full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Ca2+/calmodulin-dependent protein kinase kinase alpha
    • Calcium/calmodulin dependent protein kinase kinase
    • Calcium/calmodulin dependent protein kinase kinase 1
    • Calcium/calmodulin dependent protein kinase kinase 1 alpha
    • Calcium/calmodulin dependent protein kinase kinase alpha
    • Calcium/calmodulin-dependent protein kinase kinase 1
    • Calcium/calmodulin-dependent protein kinase kinase alpha
    • CaM kinase kinase alpha
    • CaM-kinase IV kinase
    • CaM-kinase kinase 1
    • CaM-kinase kinase alpha
    • CaM-KK 1
    • CaM-KK alpha
    • CaMKK
    • CaMKK 1
    • CaMKK alpha
    • CAMKK alpha protein
    • Camkk1
    • CAMKKA
    • DKFZp761M0423
    • KKCC1_HUMAN
    • MGC34095
    • OTTMUSP00000006419
    see all
  • 功能Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 结构域The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
    The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
  • 翻译后修饰Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant human CaMKK protein 图像

  • Kinase activity plot using ab55692. Specific acivity: 10nmol/min/mg.
  • SDS-PAGE analysis of ab55692 with molecular weight markers. Approximate molecular weight: 94kDa

Recombinant human CaMKK protein (ab55692)参考文献

ab55692 has not yet been referenced specifically in any publications.

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