Recombinant人CACNB2 protein (ab114486)

概述

  • 产品名称Recombinant人CACNB2 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ08289
    • 种属Human
    • 序列PSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKR MPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQ
    • 分子量35 kDa including tags
    • 氨基酸213 to 301

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 ug/ul.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AW060387
    • Ca(V) beta 2
    • CAB2
    • CACB2_HUMAN
    • CACNB2
    • CACNLB2
    • Calcium channel voltage dependent subunit beta 2
    • Calcium channel voltage-dependent subunit beta 2
    • Calcium channel, voltage dependent, beta 2 subunit
    • CAVB2
    • Cavbeta2
    • Cchb2
    • FLJ23743
    • Lambert Eaton Myasthenic syndrome antigen
    • Lambert Eaton myasthenic syndrome antigen B
    • Lambert-Eaton myasthenic syndrome antigen B
    • MGC129334
    • MGC129335
    • Myasthenic (Lambert Eaton) syndrome antigen B
    • Myasthenic syndrome antigen B
    • MYSB
    • Voltage dependent L type calcium channel subunit beta 2
    • Voltage-dependent L-type calcium channel subunit beta-2
    see all
  • 功能The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 组织特异性Expressed in all tissues.
  • 疾病相关Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4) [MIM:611876]. BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • 序列相似性Belongs to the calcium channel beta subunit family.
    Contains 1 SH3 domain.
  • 细胞定位Cell membrane > sarcolemma.
  • Information by UniProt

Recombinant Human CACNB2 protein 图像

  • 12.5% SDS-PAGE showing ab114486 at approximately 35.42kDa stained with Coomassie Blue.

Recombinant Human CACNB2 protein (ab114486)参考文献

ab114486 has not yet been referenced specifically in any publications.

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