Recombinant人BST2 protein (ab109848)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ10589
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMSEACRDGLRAVMECRNVTHLLQQELTEAQ KGFQDVEAQAATCNHTVMALMASLDAEKAQGQKKVEELEGEITTLNHKLQ DASAEVERLRRENQVLSVRIADKKYYPSSQDSS
    • 分子量15 kDa including tags
    • 氨基酸50 to 161
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab109848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 80 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • Bone marrow stromal antigen 2
    • Bone marrow stromal cell antigen
    • Bone marrow stromal cell antigen 2
    • BST 2
    • BST-2
    • BST2
    • BST2_HUMAN
    • CD 317
    • CD317
    • CD317 antigen
    • HM1.24 antigen
    • NPC A 7
    • Tetherin
    see all
  • 功能May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis.
  • 组织特异性Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).
  • 序列相似性Belongs to the tetherin family.
  • 结构域The extracellular coiled coil domain is important for virus retention at the cell surface and prevention of virus spreading.
  • 翻译后修饰Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation.
  • 细胞定位Golgi apparatus > trans-Golgi network. Cell membrane. Cell membrane. Late endosome. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Targeted to the trans-Golgi network by viral VPU protein.
  • Information by UniProt

Recombinant Human BST2 protein 图像

  • 15% SDS-PAGE analysis of ab109848 (3 µg).

Recombinant Human BST2 protein (ab109848)参考文献

ab109848 has not yet been referenced specifically in any publications.

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