Recombinant人Brachyury / Bry protein (ab114235)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO15178
    • 种属Human
    • 序列MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESE LWLRFKELTNEMIVTKNGRRMFPVL KVNVSGLDPNAMYSFLLDFVAAD NHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKL TN KLNGGGQIMLNSLHKYEPRIHIVRVGDPQRMITSHCFPETQFIAVT AYQNEEITALKIKYNPFAKAFLDAKERSD HKEMMEEPGDSQQPGYSQS YSDNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSSSQYPSLWS VSNGAV TPGSQAAAVSNGLGAQFFRGSPAHYTPLTHPVSAPSSSGSPL YEGAAAATDIVDSQYDAAAQGRLIASWTPVSPP SM
    • 分子量68 kDa including tags
    • 氨基酸1 to 377

技术指标

Our Abpromise guarantee covers the use of ab114235 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • BRAC_HUMAN
    • Brachyury homolog
    • Brachyury protein
    • Bry
    • MGC104817
    • Protein T
    • SAVA
    • T
    • T brachyury homolog
    • T brachyury transcription factor
    • T Protein
    • T, brachyury homolog (mouse)
    • TFT
    • Transcription factor T
    see all
  • 功能Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
  • 疾病相关Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.
    T is involved in susceptibility to the development of chordoma (CHDM) [MIM:215400]. Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Note=Susceptibility to development of chordomas is due to a T gene duplication.
  • 序列相似性Contains 1 T-box DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human Brachyury / Bry protein 图像

  • 12.5% SDS-PAGE showing ab114235 at approximately 67.54kDa stained with Coomassie Blue.

Recombinant Human Brachyury / Bry protein (ab114235)参考文献

ab114235 has not yet been referenced specifically in any publications.

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