Recombinant人BPGM protein (ab95344)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      MSKYKLIMLR HGEGAWNKEN RFCSWVDQKL NSEGMEEARN CGKQLKALNF EFDLVFTSVL NRSIHTAWLI LEELGQEWVP VESSWRLNER HYGALIGLNR EQMALNHGEE QVRLWRRSYN VTPPPIEESH PYYQEIYNDR RYKVCDVPLD QLPRSESLKD VLERLLPYWN ERIAPEVLRG KTILISAHGN SSRALLKHLE GISDEDIINI TLPTGVPILL ELDENLRAVG PHQFLGDQEA IQAAIKKVED QGKVKQAKKL EHHHHHH

技术指标

Our Abpromise guarantee covers the use of ab95344 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 纯度
    > 95 % SDS-PAGE.
    ab95344 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • 2
    • 2,3-bisphosphoglycerate mutase
    • 2,3-bisphosphoglycerate mutase, erythrocyte
    • 2,3-bisphosphoglycerate synthase
    • 2,3-diphosphoglycerate mutase
    • 3-bisphosphoglycerate mutase
    • 3-bisphosphoglycerate synthase
    • 3-diphosphoglycerate mutase
    • Ab2 098
    • AI323730
    • AL022789
    • Bisphosphoglycerate mutase
    • BPG dependent PGAM
    • BPG-dependent PGAM
    • Bpgm
    • C86192
    • DPGM
    • erythrocyte
    • Erythrocyte 2,3 bisphosphoglycerate mutase
    • PMGE_HUMAN
    see all
  • 功能
    Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
  • 疾病相关
    Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD) [MIM:222800]. A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.
  • 序列相似性
    Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
  • 翻译后修饰
    Glycation of Lys-159 in diabetic patients inactivates the enzyme.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab95344 at approximately 31kDa (3µg).

文献

ab95344 has not yet been referenced specifically in any publications.

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