Recombinant人BPGM protein (ab116488)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP07738
    • 种属Human
    • 序列MSKYKLIMLR HGEGAWNKEN RFCSWVDQKL NSEGMEEARN CGKQLKALNF EFDLVFTSVL NRSIHTAWLI LEELGQEWVP VESSWRLNERHYGALIGLNR EQMALNHGEE QVRLWRRSYN VTPPPIEESH PYYQEIYNDR RYKVCDVPLD QLPRSESLKD VLERLLPYWN ERIAPEVLRG KTILISAHGN SSRALLKHLE GISDEDIINI TLPTGVPILL ELDENLRAVG PHQFLGDQEA IQAAIKKVED QGKVKQAKKL EHHHHHH
    • 分子量31 kDa including tags
    • 氨基酸1 to 259
    • 标签His tag C-Terminus
    • 额外的序列信息BPGM Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 267 amino acids (1-259 a.a.) and having a molecular mass of 31 kDa.

技术指标

Our Abpromise guarantee covers the use of ab116488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab116488 was purified by proprietary chromatographic techniques and filter sterilized.
  • 形式Liquid
  • 补充说明although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

常规信息

  • 别名
    • 2
    • 2,3-bisphosphoglycerate mutase
    • 2,3-bisphosphoglycerate mutase, erythrocyte
    • 2,3-bisphosphoglycerate synthase
    • 2,3-diphosphoglycerate mutase
    • 3-bisphosphoglycerate mutase
    • 3-bisphosphoglycerate synthase
    • 3-diphosphoglycerate mutase
    • Ab2 098
    • AI323730
    • AL022789
    • Bisphosphoglycerate mutase
    • BPG dependent PGAM
    • BPG-dependent PGAM
    • Bpgm
    • C86192
    • DPGM
    • erythrocyte
    • Erythrocyte 2,3 bisphosphoglycerate mutase
    • PMGE_HUMAN
    see all
  • 功能Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
  • 疾病相关Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD) [MIM:222800]. A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.
  • 序列相似性Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
  • 翻译后修饰Glycation of Lys-159 in diabetic patients inactivates the enzyme.
  • Information by UniProt

Recombinant Human BPGM protein (ab116488)参考文献

ab116488 has not yet been referenced specifically in any publications.

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