Recombinant人BMPR1B protein (ab107949)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      68 kDa including tags
    • 氨基酸
      149 to 502

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技术指标

Our Abpromise guarantee covers the use of ab107949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The Specific activity of ab107949 was determined to be 23 nmol/min/mg.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 纯度
    > 85 % SDS-PAGE.
    Purity was determined to be >85% by densitometry.
  • 形式
    Liquid
  • 补充说明

    ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Activin receptor like kinase 6
    • Acvrlk6
    • ALK 6
    • ALK6
    • alk6tr
    • BMP type-1B receptor
    • BMPR IB
    • BMPR-1B
    • Bmpr1b
    • BMPRIB
    • BMR1B_HUMAN
    • Bone morphogenetic protein receptor type 1B
    • Bone morphogenetic protein receptor type IB
    • Bone morphogenetic protein receptor type-1B
    • BR 1b
    • BR1b
    • CDw 293
    • CDw293
    • CDw293 antigen
    • CFK 43a
    • CFK43a
    • Serine/threonine receptor kinase
    • zALK 6
    • zALK6
    see all
  • 功能
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.
  • 疾病相关
    Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA) [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers).
    Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo.
  • 序列相似性
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • Kinase Assay demonstrating specific activity of ab107949.
  • SDS-PAGE showing ab107949 at approximately 68kDa.

文献

ab107949 has not yet been referenced specifically in any publications.

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