The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
复溶Reconstitute in water or PBS to make a solution of no less than 100 µg/ml of BMPRIA.
Activin A receptor type II like kinase 3
Activin receptor like kinase 3
Activin receptor-like kinase 3
BMP type-1A receptor
Bone morphogenetic protein receptor type IA
Bone morphogenetic protein receptor type IA precursor
Bone morphogenetic protein receptor type-1A
Serine threonine protein kinase receptor R5
Serine threonine protein kinase receptor R5 precursor
Serine/threonine-protein kinase receptor R5
功能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
组织特异性Highly expressed in skeletal muscle.
疾病相关Juvenile polyposis syndrome Polyposis syndrome, mixed hereditary 2 A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.
序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.