Recombinant人BMP4 protein (ab92855)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸25 to 408

技术指标

Our Abpromise guarantee covers the use of ab92855 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 0.5M Imidazole
    Constituents: 30% Glycerol, 0.5M Sodium chloride, 20mM Sodium phosphate, pH 7.4

常规信息

  • 别名
    • zgc:100779
    • BMP 2B
    • BMP 4
    • BMP-2B
    • BMP-4
    • BMP2B
    • BMP2B1
    • BMP4
    • BMP4_HUMAN
    • Bone morphogenetic protein 2B
    • Bone morphogenetic protein 4
    • DVR4
    • MCOPS6
    • MGC100779
    • OFC11
    • zbmp-4
    • ZYME
    see all
  • 功能Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
  • 组织特异性Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
  • 疾病相关Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.
    Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11) [MIM:600625]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero.
  • 序列相似性Belongs to the TGF-beta family.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Recombinant Human BMP4 protein 图像

  • 10% SDS-PAGE stained with Coomassie Blue.

Recombinant Human BMP4 protein (ab92855)参考文献

ab92855 has not yet been referenced specifically in any publications.

Product Wall

Yes, this protein has a 6xHis tag as well as a maltose binding protein tag.

I hope this is helpful. Please contact me again if you have any further questions.

Thank you for contacting us and your interest in our products.


We currently have three human BMP4 protein products available.


http://www.abcam.com/BMP4-protein-MBP-ab92855.htmlRecombinant full length protein, correspondi...

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Thank you for your enquiry. The ab92855 BMP4 protein (MBP) and ab39973 BMP4 antibody have both been tested and guaranteed in western blot. The two products have not been specifically tested together in the laboratory, but as the protein is full len...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"