Recombinant人BIN1 protein (ab98238)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO00499
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMAEMGSKGVTAGKIASNVQKKLTRAQEKVL QKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASK KLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYL GQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQ NLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIR VNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQEPGETAASE AASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTAT DTDELQLRAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVF PENFTERVP
    • 分子量50 kDa including tags
    • 氨基酸1 to 439
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab98238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab98238 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • AMPH 2
    • AMPH2
    • Amphiphysin 2
    • Amphiphysin II
    • Amphiphysin like protein
    • amphiphysin-like
    • Amphiphysin-like protein
    • AMPHL
    • Bin1
    • BIN1_HUMAN
    • Box Dependant MYC Interacting Protein 1
    • Box-dependent myc-interacting protein 1
    • Bridging integrator 1
    • DKFZp547F068
    • MGC10367
    • MGC105358
    • Myc box dependent interacting protein 1
    • Myc box-dependent-interacting protein 1
    • SH3P9
    see all
  • 功能May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
  • 组织特异性Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
  • 疾病相关Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [MIM:255200]; also known as autosomal recessive myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • 序列相似性Contains 1 BAR domain.
    Contains 1 SH3 domain.
  • 翻译后修饰Phosphorylated by protein kinase C.
  • 细胞定位Cytoplasm and Nucleus.
  • Information by UniProt

Recombinant Human BIN1 protein 图像

  • 15% SDS-PAGE analysis of 3µg ab98238

Recombinant Human BIN1 protein (ab98238)参考文献

ab98238 has not yet been referenced specifically in any publications.

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