Recombinant人Bim protein (ab112387)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO43521
    • 种属Human
    • 序列MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSC DKSTQTPSPPCQAFNHYLSAMVVILEDIGDLSLCFGFIFTGLDLYGHHHS QDTEQLNHKDFS
    • 分子量39 kDa including tags
    • 氨基酸1 to 112

技术指标

Our Abpromise guarantee covers the use of ab112387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

    Other

  • 形式Liquid
  • 补充说明Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • BCL2 like 11
    • B2L11_HUMAN
    • BAM
    • Bcl 2 interacting protein Bim
    • Bcl 2 related ovarian death agonist
    • Bcl-2-like protein 11
    • BCL2 interacting mediator of cell death
    • BCL2 like 11 (apoptosis facilitator)
    • BCL2 like protein 11
    • Bcl2-interacting mediator of cell death
    • Bcl2-L-11
    • Bcl2l11
    • BIM
    • BIM alpha6
    • BIM beta6
    • BIM beta7
    • BimEL
    • BimL
    • BOD
    see all
  • 功能Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
  • 组织特异性Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
  • 序列相似性Belongs to the Bcl-2 family.
  • 结构域The BH3 motif is required for Bcl-2 binding and cytotoxicity.
  • 细胞定位Mitochondrion and Endomembrane system. Associated with intracytoplasmic membranes.
  • Information by UniProt

Recombinant Human Bim protein 图像

  • 12.5% SDS-PAGE analysis of ab112387. Stained with Coomassie Blue

Recombinant Human Bim protein (ab112387)参考文献

ab112387 has not yet been referenced specifically in any publications.

Product Wall

This product is Human Bim full-length ORF ( NP_996885.1, 1 a.a. - 112 a.a.) recombinant protein with a proprietary tag. Please contact our scientific support group for more information regarding this tag. We have not done any tests for enzymatic acti...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"