Recombinant人beta Crystallin protein (ab117029)

概述

  • 产品名称Recombinant人beta Crystallin protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP43320
    • 种属Human
    • 序列MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAG SVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPI KVDSQEHKIILYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGT WVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSVRRIRDMQWHQRGA FHPSN
    • 分子量50 kDa including tags
    • 氨基酸1 to 205

技术指标

Our Abpromise guarantee covers the use of ab117029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Beta crystallin B2
    • Beta crystallin Bp
    • Beta-B2 crystallin
    • Beta-crystallin B2
    • Beta-crystallin Bp
    • CCA 2
    • CCA2
    • CRBB2_HUMAN
    • CRY B2
    • CRYB 2
    • CRYB B2
    • CRYB2
    • CRYB2A
    • CRYBB 2
    • CRYBB2
    • Crystallin beta B2
    • D22S665
    • Eye lens structural protein
    • OTTHUMP00000198622
    see all
  • 功能Crystallins are the dominant structural components of the vertebrate eye lens.
  • 疾病相关Defects in CRYBB2 are the cause of cataract congenital cerulean type 2 (CCA2) [MIM:601547]; also known as congenital cataract blue dot type 2. A cerulean form of autosomal dominant congenital cataract. Cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract.
    Defects in CRYBB2 are the cause of cataract sutural with punctate and cerulean opacities (CSPC) [MIM:607133]. A form of cataract characterized by white opacification around the anterior and posterior Y sutures, and grayish and bluish, spindle shaped, oval punctate and cerulean opacities of various sizes arranged in lamellar form. The spots are more concentrated towards the peripheral layers and do not delineate the embryonal or fetal nucleus. Phenotypic variation with respect to the size and density of the sutural opacities as well as the number and position of punctate and cerulean spots is observed among affected subjects.
    Defects in CRYBB2 are a cause of cataract Coppock-like (CCL) [MIM:604307]. A congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited.
  • 序列相似性Belongs to the beta/gamma-crystallin family.
    Contains 4 beta/gamma crystallin 'Greek key' domains.
  • 结构域Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Information by UniProt

Recombinant Human beta Crystallin protein 图像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab117029 at approximately 50.40 kDa.

Recombinant Human beta Crystallin protein (ab117029)参考文献

ab117029 has not yet been referenced specifically in any publications.

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