Lymphoma associated zinc finger gene on chromosome 3
Zinc finger and BTB domain containing protein 27
Zinc finger and BTB domain-containing protein 27
Zinc finger protein 51
zinc finger transcription factor BCL6S
功能Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.
组织特异性Expressed in germinal center T and B cells and in primary immature dendritic cells.
疾病相关Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.